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Australian & New Zealand Childrens Haematology/Oncology Group

Clinical Trials

FORUM: Allogeneic Stem Cell Transplantation in Children and Adolescents with Acute Lymphoblastic Leukaemia – For Omitting Radiotherapy in the Under Majority age

Leukaemia: Acute Lymphoblastic Leukaemia (high risk)

Status: Completed

Some children and adolescents with ALL will require a bone marrow transplant. Prior to transplant, some patients will receive total body irradiation (TBI), which has a number of debilitating side effects for the patient. This study will examine whether a three-drug chemotherapy combination without TBI works as well as a single drug treatment with TBI. In addition this study will examine the impact of bone marrow transplant donor options on the child or adolescent’s outcomes.

Disease Stage: Remission

Patient Age Range: At diagnosis <18 years; age at transplant <21 years

Sample Size: 1000

Recruitment period: 5 years

Trial Sponsors:

  • International: St. Anna Kinderkrebsforschung, Vienna, Austria

  • National: ANZCHOG

ANZCHOG acknowledges the valuable support of FORUM by the Australian Government through Cancer Australia’s Priority-driven Collaborative Cancer Research Scheme.