Australian & New Zealand Childrens Haematology/Oncology Group

Clinical Trials

COZMOS: Phase I/Ib trial of Combined 5’azacitidine and carboplatin for recurrent/refractory paediatric brain and solid tumours

Brain and solid tumours

New treatment options for children with relapsed and recurrent brain and solid tumours is limited. Recent research shows that many of  these tumours have a general change in their DNA (methylation), and altering methylation may stop the tumours. This international trial will test the safety of treating children with a methylation inhibitor (azacitidine) and a standard chemotherapy drug (carboplatin), in the first step of exploring this new treatment option.

Disease stage: Relapsed and recurrent cancers

Patient age range: 1-18 years old

Trial sponsors:

  • National: ANZCHOG
  • International: Hospital for Sick Children, Toronto.

Read more at the Clinical Trial Registry 

ANZCHOG acknowledges the valuable support of COZMOS by the Australian Brain Cancer Mission and Carrie's Beanies for Brain Cancer