Last Updated | 31 March 2026

Firefly-2

A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With paediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy
External Registry
Site Status Queensland Children's Hospital Sydney Children's Hospital Perth Children's Hospital Children's Hospital at Westmead Starship Children's Hospital Royal Children's Hospital Women's and Children's Hospital
Queensland Children's Hospital (QLD)
John Hunter Children's Hospital (NSW)
Sydney Children's Hospital (NSW)
Monash Health Clayton (VIC)
Royal Children's Hospital (VIC)
Women's and Children's Hospital (SA)
Perth Children's Hospital (WA)
Royal Hobart Hospital (TAS)
Children's Hospital at Westmead (NSW)
Starship Children's Hospital (NZ)
Christchurch Hospital (NZ)
Preparing to Open
Open
Temporarily Closed
Closed
Complete
Adult Sites These sites are not monitored. Status may vary.
Diagnosis Stage Newly Diagnosed
National Sponsor Day One Biopharmaceuticals, Inc.
Open Date 19/05/2023
Conditions Low-Grade Glioma
Patient Range <25 years
Disease Type Brain and Spinal (Central Nervous System) Tumours
Study Type Interventional
International Sponsor N/A

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