Last Updated | 31 March 2026

PEPN2121

A Phase 1/2 Study of Tiragolumab and Atezolizumab in Patients with Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors
External Registry
Site Status Queensland Children's Hospital Sydney Children's Hospital Royal Children's Hospital
Queensland Children's Hospital (QLD)
John Hunter Children's Hospital (NSW)
Sydney Children's Hospital (NSW)
Monash Health Clayton (VIC)
Royal Children's Hospital (VIC)
Women's and Children's Hospital (SA)
Perth Children's Hospital (WA)
Royal Hobart Hospital (TAS)
Children's Hospital at Westmead (NSW)
Starship Children's Hospital (NZ)
Christchurch Hospital (NZ)
Preparing to Open
Open
Temporarily Closed
Closed
Complete
Adult Sites These sites are not monitored. Status may vary.
Diagnosis Stage Newly Diagnosed, Relapsed/Refractory
National Sponsor National Cancer Institute (NCI)
Open Date 16/08/2024
Conditions Atypical Teratoid/Rhabdoid Tumor
Epithelioid Sarcoma
Kidney Medullary Carcinoma
Malignant Solid Neoplasm
Poorly Differentiated Chordoma
Recurrent Atypical Teratoid/Rhabdoid Tumor
Recurrent Chordoma
Recurrent Epithelioid Sarcoma
Recurrent Kidney Medullary Carcinoma
Recurrent Malignant Solid Neoplasm
Recurrent Rhabdoid Tumor
Refractory Atypical Teratoid/Rhabdoid Tumor
Refractory Chordoma
Refractory Epithelioid Sarcoma
Refractory Kidney Medullary Carcinoma
Refractory Malignant Solid Neoplasm
Refractory Rhabdoid Tumor
Rhabdoid Tumor
Patient Range >12 months
Disease Type , Brain and Spinal (Central Nervous System) Tumours, Digestive System Tumours, Endocrine Tumours, Eye Tumours, Female genital tumours, Genetic tumour syndromes, Germ Cell Tumours, Leukaemia / Lymphoma / Blood Disorders, Head and neck tumours, Neuroblastoma and Ganglioneuroblastoma, Kidney (Renal) Tumours, Skin tumours, Soft Tissue and Bone Tumours (Sarcoma), Chest and Lung (Thoracic) Tumours
Study Type Interventional
International Sponsor N/A

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