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John Hunter Children's Hospital

John Hunter Children’s Hospital provides specialist paediatric cancer care for children and adolescents across the Hunter New England region and northern New South Wales, delivering treatment through a coordinated, multidisciplinary team.

As part of the ANZCHOG network, the site supports access to clinical trials and collaborates closely with major national and international centres to ensure children receive the best possible care and opportunities to participate in research.

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Recruiting Trials

Open
Phase 3

AALL1732

A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
1 year

|

25 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Royal Hobart Hospital, Starship Children’s Hospital, Christchurch Hospital
Leukaemia / Lymphoma / Blood Disorders
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Open
Phase 2

AALL1821

Phase 2 Study of Blinatumomab (NSC# 765986, IND# 125462) in Combination with Nivolumab (NSC# 748726, IND# 125462), a Checkpoint Inhibitor of PD-1, in B-ALL Patients
1 year

|

31 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Monash Health Clayton, Perth Children’s Hospital, Starship Children’s Hospital
Leukaemia / Lymphoma / Blood Disorders
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Preparing to Open
Phase 3

AALL2131

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)
>1 year

|

46 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Leukaemia / Lymphoma / Blood Disorders
Learn More
Open
Phase 3

AAML1831

A Phase 3 Randomized Trial for Patients With De Novo AML Comparing Standard Therapy Including Gemtuzumab Ozogamicin (GO) to CPX-351 With GO, and the Addition of the FLT3 Inhibitor Gilteritinib for Patients With FLT3 Mutations
<21 years
Queensland Children’s Hospital, John Hunter Children’s Hospital
Leukaemia / Lymphoma / Blood Disorders
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Open
Phase 2

ACNS2321

A Phase II Trial Evaluating Chemotherapy followed by Response-Based Reduced Radiation Therapy for Patient with Central Nervous System Germinomas
3 years

|

29 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital
Brain and Spinal (Central Nervous System) Tumours
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Open

ACOR

Australian Cardio-Oncology Registry
<35 years
John Hunter Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead
, Brain and Spinal (Central Nervous System) Tumours, Digestive System Tumours, Endocrine Tumours, Eye Tumours, Female genital tumours, Genetic tumour syndromes, Germ Cell Tumours, Leukaemia / Lymphoma / Blood Disorders, Head and neck tumours, Neuroblastoma and Ganglioneuroblastoma, Kidney (Renal) Tumours, Skin tumours, Soft Tissue and Bone Tumours (Sarcoma), Chest and Lung (Thoracic) Tumours
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Open
Phase 3

AGCT1531

A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk paediatric and Adult Patients with Germ Cell Tumors
Various depending on risk group & consult protocol
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Germ Cell Tumours
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Open
Phase 2

ANHL2121

Phase 2 Study of Tovorafenib (DAY101) in Relapsed and Refractory Langerhans Cell Histiocytosis
189 days

|

22 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead
Leukaemia / Lymphoma / Blood Disorders
Learn More
Open
Phase 3

ANZUP 1302

Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic Germ Cell Tumours
11 years

|

50 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Starship Children’s Hospital, Christchurch Hospital
Germ Cell Tumours
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Open
Phase 3

AOST2031

A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
<50 years
John Hunter Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Soft Tissue and Bone Tumours (Sarcoma)
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Open
Phase 2/3

AOST2032

A Feasibility and Randomized Phase 2/3 Study of the VEFGR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma
<40 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Soft Tissue and Bone Tumours (Sarcoma)
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Open
Phase 1/2

APAL2020SC

paediatric Acute Leukemia (PedAL) Screening Trial – Developing New Therapies for Relapsed Leukemias
<22 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Leukaemia / Lymphoma / Blood Disorders
Learn More
Open

APEC14B1

Project: EveryChild A Registry and Eligibility Screening and Biology and Outcome Study
<25 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Royal Hobart Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
Learn More
Open
Phase 2

ARAR2221

A Phase 2 Study Using Chemoimmunotherapy with Gemcitabine, Cisplatin and Nivolumab in Newly Diagnosed Nasopharyngeal Carcinoma (NPC)
<21 years
John Hunter Children’s Hospital, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Head and neck tumours
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Open
Phase 2

AREN1921

Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)
<30 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Renal and male genital tumours
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Open
Phase 3

AREN2231

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
<30 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Kidney (Renal) Tumours
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Open

HoTRODS

Post mortem tumour donation for Diffuse Intrinsic Pontine Glioma – developing DIPG cell cultures to test novel therapeutic strategies
No limits
John Hunter Children’s Hospital, Sydney Children’s Hospital, Perth Children’s Hospital, Starship Children’s Hospital
CNS tumours
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Open
Phase 2/3

MINI

A prospective, multi randomised, blinded, two-arm parallel trial of Medicinal Cannabis products for symptom burden in children with advanced cancer
6 months

|

21 years
John Hunter Children’s Hospital, Royal Children’s Hospital
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
Learn More
Open
Phase 1

P305

Phase I clinical trial of adoptive transfer of multi-virus-specific T cells into TCRaß+/CD19+-depleted haploidentical HSCT recipients
3 months

|

18 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Royal Children’s Hospital
Haematolymphoid disorders
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Open

PPB DICER

International Pleuropulmonary Blastoma Registry for PPB, DICER1 and Associated Conditions
<100 years
John Hunter Children’s Hospital, Perth Children’s Hospital, Starship Children’s Hospital
CNS tumours, Genetic tumour syndromes, Peripheral neuroblastic tumours, Renal and male genital tumours, Soft tissue and bone tumours, Thoracic tumours
Learn More

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