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Sydney Children's Hospital

Sydney Children’s Hospital combines specialist paediatric cancer care with a strong culture of research and innovation, serving children and adolescents from across New South Wales.

Located within a major academic health precinct, the hospital brings together expert multidisciplinary teams and close research partnerships, enabling early access to clinical trials and new therapies through the ANZCHOG network.

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Recruiting Trials

Open
Phase 3

AAML1531

Risk-stratified Therapy for Acute Myeloid Leukemia in Down Syndrome
91 days

|

3 years
Sydney Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Christchurch Hospital
Leukaemia / Lymphoma / Blood Disorders
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Open
Phase 1/2

ACNS1821

A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed paediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
12 months

|

21 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Brain and Spinal (Central Nervous System) Tumours
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Open
Phase 2

ACNS2021

A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor
3 years

|

29 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Brain and Spinal (Central Nervous System) Tumours
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Open
Phase 2

ACNS2321

A Phase II Trial Evaluating Chemotherapy followed by Response-Based Reduced Radiation Therapy for Patient with Central Nervous System Germinomas
3 years

|

29 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital
Brain and Spinal (Central Nervous System) Tumours
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Open
Phase 3

AGCT1531

A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk paediatric and Adult Patients with Germ Cell Tumors
Various depending on risk group & consult protocol
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Germ Cell Tumours
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Open
Phase 2

ANBL1821

A Phase 2 Randomised Study of Irinotecan/Temozolomide/Dinutuximab with or without Eflornithine (DFMO) (IND# TBD) in Children with Relapsed& Refractory or Progressive Neuroblastoma
>1 year
Queensland Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead
Neuroblastoma and Ganglioneuroblastoma
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Open
Phase 3

ANBL2131

A Phase 3 Study of Dinutuximab Added to Intensive Multimodal Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
<30 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Perth Children’s Hospital, Starship Children’s Hospital
Neuroblastoma and Ganglioneuroblastoma
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Open
Phase 2/3

AOST2032

A Feasibility and Randomized Phase 2/3 Study of the VEFGR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma
<40 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Soft Tissue and Bone Tumours (Sarcoma)
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Open

APEC14B1

Project: EveryChild A Registry and Eligibility Screening and Biology and Outcome Study
<25 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Royal Hobart Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
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Open
Phase 3

AREN2231

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
<30 years
Queensland Children’s Hospital, John Hunter Children’s Hospital, Sydney Children’s Hospital, Monash Health Clayton, Royal Children’s Hospital, Starship Children’s Hospital, Christchurch Hospital
Renal and male genital tumours
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Open
Phase 3

ARST2032

A Prospective Phase 3 Study of Patients With Newly Diagnosed Very Low-Risk and Low-Risk Fusion Negative Rhabdomyosarcoma
<21 years
Sydney Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital, Christchurch Hospital
Soft tissue and bone tumours
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Open
Phase 2

DAY101-001 (FIREFLY)

A Phase 2, Open-Label, Multicenter Study to Evaluate the Safety and Efficacy of the Oral Pan-RAF Inhibitor DAY101 in paediatric Patients With BRAF-Altered, Recurrent or Progressive Low-Grade Glioma
6 months

|

25 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Women’s and Children’s Hospital, Children’s Hospital at Westmead
CNS tumours
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Open
Phase 3

Firefly-2

A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With paediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy
<25 years
Sydney Children’s Hospital, Women’s and Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead, Starship Children’s Hospital
CNS tumours
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Open
Phase 2

FORTE

A Phase 2 Master Protocol to assess the efficacy and safety of FORE8394, an inhibitor of BRAF Class 1 and Class 2 alterations, in participants with cancer harboring BRAF alterations
>10 years
Sydney Children’s Hospital
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
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Open

HoTRODS

Post mortem tumour donation for Diffuse Intrinsic Pontine Glioma – developing DIPG cell cultures to test novel therapeutic strategies
No limits
John Hunter Children’s Hospital, Sydney Children’s Hospital, Perth Children’s Hospital, Starship Children’s Hospital
CNS tumours
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Open
Phase 1/2

iMATRIX (GO42286)

A Phase I/II, Open-Label, Multicenter, Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in paediatric Patients With ALK Fusion-Positive Solid or CNS Tumors for Whom Prior Treatment Has Proven to be Ineffective or for Whom There is No Satisfactory Treatment Available
<17 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
Learn More
Open

Levi's CATCH

LEVERAGING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING T CELLS FOR CHILDREN WITH DIFFUSE MIDLINE GLIOMA (LEVI’S-CATCH)
<21 years
Sydney Children’s Hospital, Children’s Hospital at Westmead
CNS tumours
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Open
Phase 1/2

LIGHTBEAM 01A MK-9999-01A

LIGHTBEAM-U01 Substudy 01A: A Phase 1/2 Substudy to Evaluate the Safety and Efficacy of Zilovertamab Vedotin in paediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors
6 months

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25 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital
Haematolymphoid disorders, Peripheral neuroblastic tumours, Soft tissue and bone tumours
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Open
Phase 1/2

LIGHTBEAM 01C MK9999-01C

LIGHTBEAM-U01 Substudy 01C: A Phase 1/2 Substudy to Evaluate the Safety and Efficacy of Patritumab Deruta in paediatric Participants With Relapsed or Refractory Solid Tumors
1 months

|

17 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
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Preparing to Open

LIGHTBEAM 01D

A Phase 1b/2 Substudy to Evaluate the Safety and Efficacy of Ifinatamab Deruxtecan in paediatric Participants With Relapsed or Refractory Solid Tumors
Sydney Children’s Hospital, Royal Children’s Hospital
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Closed to Recruitment
Phase 1/2

LOXO-TRK-15003

A Phase 1/2 Study of the Oral TRK Inhibitor LOXO-101 in Pediatric Patients With Advanced Solid or Primary Central Nervous System Tumors
<21 years
N/A
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
Learn More
Open
Phase 3

ONC201-108

ONC201 for the Treatment of Newly Diagnosed H3 K27M-mutant Diffuse Glioma Following Completion of Radiotherapy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study
No limit
Queensland Children’s Hospital, Sydney Children’s Hospital, Perth Children’s Hospital, Royal Hobart Hospital
CNS tumours
Learn More
Open

SCRIPT

Using single-cell RNA-sequencing to identify clonal enrichment in paediatric solid tumours
<18 years
Sydney Children’s Hospital
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
Learn More
Open
Phase 3

TAK-620-2004

A Phase 3, Open-label, Single-arm, Repeated-dose Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Antiviral Activity of Maribavir for the Treatment of Cytomegalovirus (CMV) Infection in Children and Adolescents Who Have Received a Hematopoietic Stem Cell Transplant (HSCT) or a Solid Organ Transplant (SOT)
<17 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Royal Children’s Hospital, Perth Children’s Hospital
Haematolymphoid disorders
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Open
Phase 1/2

TPX-0005-07

A phase 1/2, open-label safety, tolerability, pharmacokinetics and anti-tumour activity study of repotrectinib in paediatric and young adult subjects with advanced or metastatic malignancies harbouring ALK, ROS1 or NTRK1-3 alterations
<25 years
Queensland Children’s Hospital, Sydney Children’s Hospital, Perth Children’s Hospital, Children’s Hospital at Westmead
Breast tumours, CNS tumours, Digestive system tumours, Endocrine tumours, Eye tumours, Female genital tumours, Genetic tumour syndromes, Germ cell tumours, Haematolymphoid disorders, Head and neck tumours, Peripheral neuroblastic tumours, Renal and male genital tumours, Skin tumours, Soft tissue and bone tumours, Thoracic tumours
Learn More

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