The AIM BRAIN Project is a national diagnostic protocol aimed at integrating advanced molecular characterisation into the standard of care for paediatric neuro oncology. The study utilises high resolution DNA methylation profiling and next generation sequencing (NGS) to refine the classification of central nervous system (CNS) tumours beyond traditional histopathology. The primary objective is to provide clinicians with comprehensive molecular data to improve diagnostic accuracy, risk stratification, and the identification of actionable therapeutic targets. By correlating molecular subgroups with clinical outcomes, the project seeks to validate the utility of epigenetic signatures in predicting disease behaviour and guiding trial enrollment.