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Glo-BNHL (RG_21-124)

A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma
External Registry

Trial Summary

This trial is for children and young adults with B-cell Non-Hodgkin Lymphoma that has come back or hasn’t responded to treatment. This trial provides a range of treatment options to patients where eligible; as the trial consists of three parallel treatment arms that can be amended, added, or removed to reflect the prioritisation of safe of effective medications/treatments.
An adaptive prospective international multicentre platform clinical trial designed to evaluate the safety and efficacy of novel agents for the treatment of children, adolescents, and young adults (CAYA) with relapsed and/or refractory B-cell non-Hodgkin Lymphoma (r/r BNHL). The platform consists of three parallel treatment arms, each one investigating a different novel agent. The platform allows the testing of a pipeline of novel agents in each treatment arm consecutively.
Site Status
Queensland Children's Hospital (QLD)
John Hunter Children's Hospital (NSW)
Sydney Children's Hospital (NSW)
Monash Children's Hospital (VIC)
Royal Children's Hospital (VIC)
Women's and Children's Hospital (SA)
Perth Children's Hospital (WA)
Royal Hobart Hospital (TAS)
Children's Hospital at Westmead (NSW)
Starship Children's Hospital (NZ)
Christchurch Hospital (NZ)
Chris O'Brien Lifehouse
Peter MacCallum Cancer Centre
Prince of Wales Hospital
Princess Alexandra Hospital
Royal Adelaide Hospital
Sir Charles Gardiner Hospital
Westmead Adult Hospital
Calvary Mater Newcastle
Preparing to open
Open
Closed
Complete
Adult Sites These sites are not monitored. Status may vary.
Diagnosis Stage Relapsed/Refractory
National Sponsor ANZCHOG
Open Date 12/02/2026
Conditions B-cell Non-Hodgkin Lymphoma
Patient Range - ≤ 25 years
0 50 99+
Disease Type Disease Type, Leukaemia / Lymphoma / Blood Disorders
Study Type Interventional
International Sponsor University of Birmingham
13

Funders

ANZCHOG acknowledges the valuable support of Glo-BNHL (RG_21-124) by:
University of Birmingham
Media & Publication Highlights

ANZCHOG acknowledges Traditional Owners of Country throughout Australia and recognises the continuing connection to lands, waters and communities. We pay our respect to Aboriginal and Torres Strait Islander cultures, and to Elders both past and present. We acknowledge Māori as tangata whenua of Aotearoa New Zealand and as Treaty partners with the Crown as agreed in Te Tiriti o Waitangi. 

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