This study will investigate the effectiveness of the introduction of a new drug Blinotumomab to the standard treatment for infants diagnosed with acute lymphoblastic leukaemia (ALL). Blinotumomab attaches to the cancer cells, causing them to break down and die. Infants will be given the standard chemotherapy treatment for the first month, followed by an additional month of continuous treatment with Blinotumomab. This will require an extra period of hospitalisation.
The patient will have been treated according to the Interfant-06 protocol where they will have received standard induction therapy. If the patient is eligible for the current study, blinatumomab will be added to standard arm (1B) of the Interfant-06 protocol. The patient will receive 1 course of blinatumomab. The blinatumomab course (15 micrograms/m2/day) consists of a 4-week continuous intravenous infusion. The patient will be closely monitored during the first 72 hours of treatment and will be admitted to the hospital preferably for the full 4 weeks of the blinatumomab infusion with a minimum admission of 7 days. Following treatment with blinatumomab, the patient wil lrecommence standard treatment according to Interfant-06 (protocol 1B).