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Australian & New Zealand Childrens Haematology/Oncology Group

Clinical Trials

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Solid Tumours: Malignant Rhabdoid Tumour, Atypical Teratoid Rhabdoid Tumour, Neuroblastoma, Osteoscaroma
Status: Open NSW , QLD , TAS , VIC , WA , SA , New Zealand

NORTH Trial: A phase II study of Panobinostat in Paediatric, Adolescent and Young Adults with Solid Tumours including Neuroblastoma, Osteosarcoma, Malignant Rhabdoid Tumour/Atypical Teratoid Rhabdoid Tumours

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Brain and Spinal Cord Tumours
Status: Open NSW , QLD , TAS , VIC , WA , SA , New Zealand

AIM BRAIN: Access to Innovative Molecular Diagnostic Profiling for Paediatric Brain Tumours

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Sarcoma: Ewing sarcoma
Status: Open NSW , QLD , VIC , WA , SA , New Zealand

rEECur: An international randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma

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Lymphoma: Classical Hodgkin Lymphoma
Status: Open NSW , QLD , TAS , VIC , WA , New Zealand

EuroNet-PHL-C2: European Network of Paediatric Hodgkin Lymphoma Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents

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Leukaemia: Acute Lymphoblastic Leukaemia (high risk)
Status: Open NSW , VIC , SA

IntReALL HR 2010: International study for treatment of childhood Relapsed high risk ALL (HR-ALL) 2010: A randomized Phase II Study

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Brain tumour: Low grade glioma (LGG)
Status: Open NSW , QLD , VIC , WA , SA , New Zealand

LGG-Avastin : A phase II, open-labeled, multi-center, randomized controlled trial of Vinblastine +/- Bevacizumab (Avastin) for the treatment of chemotherapy-naïve children with unresectable or progressive low grade glioma

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Leukaemia: Acute lymphoblastic leukaemia (MLL rearranged)
Status: Open NSW , QLD , VIC

Blin-fant Study: A pilot study to test the feasibility, safety and efficacy of the addition of the BiTE antibody Blinatumomab to the Interfant-06 backbone in infants with MLL-rearranged acute lymphoblastic leukemia: A collaborative study of the Interfant network

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Leukaemia: AML and High Risk MDS
Status: Open NSW , QLD , VIC , WA , SA , New Zealand

MyeChild 01: International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia: Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy

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Leukaemia, solid tumours and brain tumours
Status: Open NSW , QLD , WA , SA

PARC: An international phase I/II study evaluating the safety and activity of Pegylated recombinant human Arginase (BCT-100) in Relapsed/refractory cancers of Children and young adults.

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High-risk cancers
Status: Open NSW , QLD , TAS , VIC , WA , SA

PRISM: PRecISion Medicine for Children with Cancer

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High risk haematological malignancy, or a non-malignant disease
Status: Open NSW , QLD , VIC , WA , New Zealand

Pαβlo: Paediatric αβ haploidentical transplantation

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Brain and solid tumours
Status: Open NSW , QLD , VIC , WA , SA

COZMOS: Phase I/Ib trial of Combined 5’azacitidine and carboplatin for recurrent/refractory paediatric brain and solid tumours

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Brain cancer: Medulloblastoma
Status: Open NSW , QLD , VIC , WA

SJ ELiOT: Phase 1 Evaluation of LY2606368, a CHK inhibitor, in combination with cyclophosphamide or gemcitabine for children & adolescents with recurrent medulloblastoma tumours.

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Hypermutant Cancers
Status: Open NSW , QLD , SA

Hypermutant Cancers Trial: A Pilot Study of Nivolumab in Paediatric Patients with Hypermutant Cancers

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Rhabdomyosarcoma
Status: Open NSW

Far-RMS: Frontline and Relapse Study in RhabdomyoSarcoma Study

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NF-1 associated plexiform neurofibromas or progressive optic pathway gliomas
Status: Open QLD , WA , New Zealand

TINT: A phase II study of trametinib in paediatric, adolescent and young adult patients with Neurofibromatosis type 1 associated plexiform neurofibromas or progressive optic pathway gliomas.

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Neuroblastoma
Status: Open NSW , VIC , WA

LINES: European Low and Intermediate Risk Neuroblastoma (Phase III SIOPEN study)

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Peripheral neuroblastic tumours
Status: Open NSW , QLD , TAS , VIC , WA , SA

SIOPEN SCI Registry: Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting with Spinal Canal Involvement

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Progressive high-risk solid tumours or central nervous system tumours
Status: Open NSW , VIC , WA

INFORM2 NivEnt: Phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies

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High Grade Glioma(NICHE-HGG)
Status: Open WA

PNOC019/NICHE-HGG: A Randomized, Double-Blinded, Pilot Trial of Neoadjuvant Checkpoint Inhibition followed by Combination Adjuvant Checkpoint Inhibition in Children and Young Adults with Recurrent or Progressive

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Diffuse Intrinsic Pontine Glioma (DIPG)
Status: Open NSW , QLD , VIC , WA , New Zealand

ReRAD: A Phase II Canadian Paediatric Brain Tumour Consortium Study of Re – Irradiation as Treatment of Progressive or Recurrent Diffuse Intrinsic Pontine Glioma

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Acute lymphoblastic leukemia
Status: Open NSW

Study 10: International collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia (AIEOP-BFM ALL 2017)

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