Open | Australian & New Zealand Childrens Haematology/Oncology Group

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Brain and Spinal Cord Tumours

Status: Open NSW , QLD , TAS , VIC , WA , SA , New Zealand

AIM BRAIN: Access to Innovative Molecular Diagnostic Profiling for Paediatric Brain Tumours

Sarcoma: Ewing sarcoma

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

rEECur: An international randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma

Lymphoma: Classical Hodgkin Lymphoma

Status: Open NSW , QLD , TAS , VIC , WA , New Zealand

EuroNet-PHL-C2: European Network of Paediatric Hodgkin Lymphoma Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents

Brain tumour: Low grade glioma (LGG)

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

LGG-Avastin : A phase II, open-labeled, multi-center, randomized controlled trial of Vinblastine +/- Bevacizumab (Avastin) for the treatment of chemotherapy-naïve children with unresectable or progressive low grade glioma

Leukaemia: AML and High Risk MDS

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

MyeChild 01: International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia: Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy

Leukaemia, solid tumours and brain tumours

Status: Open NSW , QLD , VIC , WA , SA

PARC: An international phase I/II study evaluating the safety and activity of Pegylated recombinant human Arginase (BCT-100) in Relapsed/refractory cancers of Children and young adults.

High-risk cancers

Status: Open NSW , QLD , TAS , VIC , WA , SA

PRISM: PRecISion Medicine for Children with Cancer

High risk haematological malignancy, or a non-malignant disease

Status: Open NSW , QLD , VIC , WA , New Zealand

Pαβlo: Paediatric αβ haploidentical transplantation

Brain and solid tumours

Status: Open NSW , QLD , VIC , WA , SA

COZMOS: Phase I/Ib trial of Combined 5’azacitidine and carboplatin for recurrent/refractory paediatric brain and solid tumours

Brain cancer: Medulloblastoma

Status: Open NSW , QLD , VIC , WA

SJ ELiOT: Phase 1 Evaluation of LY2606368, a CHK inhibitor, in combination with cyclophosphamide or gemcitabine for children & adolescents with recurrent medulloblastoma tumours.

Rhabdomyosarcoma

Status: Open NSW , VIC

Far-RMS: Frontline and Relapse Study in RhabdomyoSarcoma Study

NF-1 associated plexiform neurofibromas or progressive optic pathway gliomas

Status: Open QLD , TAS , VIC , WA , New Zealand

TINT: A phase II study of trametinib in paediatric, adolescent and young adult patients with Neurofibromatosis type 1 associated plexiform neurofibromas or progressive optic pathway gliomas.

Neuroblastoma

Status: Open NSW , VIC , WA

LINES: European Low and Intermediate Risk Neuroblastoma (Phase III SIOPEN study)

Peripheral neuroblastic tumours

Status: Open NSW , QLD , TAS , VIC , WA , SA

SIOPEN SCI Registry: Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting with Spinal Canal Involvement

Progressive high-risk solid tumours or central nervous system tumours

Status: Open NSW , VIC , WA

INFORM2 NivEnt: Phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies

High Grade Glioma(NICHE-HGG)

Status: Open NSW , WA

PNOC019/NICHE-HGG: A Randomized, Double-Blinded, Pilot Trial of Neoadjuvant Checkpoint Inhibition followed by Combination Adjuvant Checkpoint Inhibition in Children and Young Adults with Recurrent or Progressive

Diffuse Intrinsic Pontine Glioma (DIPG)

Status: Open NSW , QLD , VIC , WA , New Zealand

ReRAD: A Phase II Canadian Paediatric Brain Tumour Consortium Study of Re – Irradiation as Treatment of Progressive or Recurrent Diffuse Intrinsic Pontine Glioma

High Grade Glioma

Status: Open WA

CONNECT 1903: A Pilot and Surgical Study of Larotrectinib for Treatment of Children with Newly-Diagnosed High-Grade Glioma with NTRK Fusion

Acute lymphoblastic leukemia

Status: Open NSW

Study 10: International collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia (AIEOP-BFM ALL 2017)

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