Open - Australian & New Zealand Childrens Haematology/Oncology Group

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Adamantinomatous Craniopharyngioma

Status: Open NSW , WA

CONNECT1905: Phase 2 Study of Systemic IL-6 Receptor Antagonist ACTEMRA® (tocilizumab) for the treatment of Progressive/Recurrent Pediatric Adamantinomatous Craniopharyngioma

Medulloblastoma

Status: Open NSW , VIC

MetMED: Phase III randomized double-blind placebo-controlled trial of metformin for white matter repair and cognitive recovery in paediatric brain tumour patients

Diffuse Midline Gliomas

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

PNOC-022 (DMG-ACT): A Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas including Diffuse Intrinsic Pontine Gliomas at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression.

Acute lymphoblastic leukemia

Status: Open NSW

Study 10: International collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia (AIEOP-BFM ALL 2017)

High Grade Glioma

Status: Open NSW , QLD , WA

CONNECT 1903: A Pilot and Surgical Study of Larotrectinib for Treatment of Children with Newly-Diagnosed High-Grade Glioma with NTRK Fusion

Diffuse Intrinsic Pontine Glioma (DIPG)

Status: Open NSW , QLD , VIC , WA , New Zealand

ReRAD: A Phase II Canadian Paediatric Brain Tumour Consortium Study of Re – Irradiation as Treatment of Progressive or Recurrent Diffuse Intrinsic Pontine Glioma

Progressive high-risk solid tumours or central nervous system tumours

Status: Open NSW , VIC , WA

INFORM2 NivEnt: Phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies

Solid tumour: High risk neuroblastoma

Status: Open NSW

HR-NBM study: High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

Peripheral neuroblastic tumours

Status: Open NSW , QLD , TAS , VIC , WA , SA

SIOPEN SCI Registry: Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting with Spinal Canal Involvement

NF-1 associated plexiform neurofibromas or progressive optic pathway gliomas

Status: Open NSW , QLD , TAS , VIC , WA , SA , New Zealand

TINT: A phase II study of trametinib in paediatric, adolescent and young adult patients with Neurofibromatosis type 1 associated plexiform neurofibromas or progressive optic pathway gliomas.

Rhabdomyosarcoma

Status: Open NSW , VIC , WA , New Zealand

FaR-RMS: Frontline and Relapse Study in RhabdomyoSarcoma Study

High-risk cancers

Status: Open NSW , QLD , TAS , VIC , WA , SA

PRISM: PRecISion Medicine for Children with Cancer

Brain tumour: Low grade glioma (LGG)

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

LGG-Avastin: A phase II, open-labeled, multi-center, randomized controlled trial of Vinblastine +/- Bevacizumab (Avastin) for the treatment of chemotherapy-naïve children with unresectable or progressive low grade glioma

Sarcoma: Ewing sarcoma

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

rEECur: An international randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma

Adamantinomatous Craniopharyngioma

Status: Open NSW , WA

CONNECT2108: Phase 2 Study of the MEK inhibitor MEKTOVI® (binimetinib) for the treatment of Progressive/Recurrent Pediatric Adamantinomatous Craniopharyngioma

CNS Tumours, including ependymoma and newly diagnosed DIPG/DMG

Status: Open NSW , QLD , WA

DART: Phase I/II Trial of Deflexifol for Refractory or Recurrent Paediatric Central Nervous System (CNS) Tumours

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