Open | Australian & New Zealand Childrens Haematology/Oncology Group

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Solid Tumours: Malignant Rhabdoid Tumour, Atypical Teratoid Rhabdoid Tumour, Neuroblastoma, Osteoscaroma

Status: Open NSW , QLD , TAS , VIC , WA , SA , New Zealand

NORTH Trial: A phase II study of Panobinostat in Paediatric, Adolescent and Young Adults with Solid Tumours including Neuroblastoma, Osteosarcoma, Malignant Rhabdoid Tumour/Atypical Teratoid Rhabdoid Tumours

Brain and Spinal Cord Tumours

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

AIM BRAIN: Access to Innovative Molecular Diagnostic Profiling for Paediatric Brain Tumours

Sarcoma: Ewing sarcoma

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

rEECur: An international randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma

Lymphoma: Classical Hodgkin Lymphoma

Status: Open NSW , QLD , TAS , VIC , WA , New Zealand

EuroNet-PHL-C2: European Network of Paediatric Hodgkin Lymphoma Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents

Leukaemia: Acute Lymphoblastic Leukaemia (high risk)

Status: Open NSW , VIC , SA

IntReALL HR 2010: International study for treatment of childhood Relapsed high risk ALL (HR-ALL) 2010: A randomized Phase II Study

Brain tumour: Low grade glioma (LGG)

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

LGG-Avastin : A phase II, open-labeled, multi-center, randomized controlled trial of Vinblastine +/- Bevacizumab (Avastin) for the treatment of chemotherapy-naïve children with unresectable or progressive low grade glioma

Leukaemia: Acute lymphoblastic leukaemia (MLL rearranged)

Status: Open NSW , QLD , VIC

Blin-fant Study: A pilot study to test the feasibility, safety and efficacy of the addition of the BiTE antibody Blinatumomab to the Interfant-06 backbone in infants with MLL-rearranged acute lymphoblastic leukemia: A collaborative study of the Interfant network

Leukaemia: AML and High Risk MDS

Status: Open NSW , QLD , VIC , WA , SA , New Zealand

MyeChild 01: International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia: Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy

Leukaemia, solid tumours and brain tumours

Status: Open NSW , QLD , WA , SA

PARC: An international phase I/II study evaluating the safety and activity of Pegylated recombinant human Arginase (BCT-100) in Relapsed/refractory cancers of Children and young adults.

High-risk cancers

Status: Open NSW , QLD , TAS , VIC , WA , SA

PRISM: PRecISion Medicine for Children with Cancer

High risk haematological malignancy, or a non-malignant disease

Status: Open NSW , QLD , VIC , WA , New Zealand

Pαβlo: Paediatric αβ haploidentical transplantation

Brain and solid tumours

Status: Open NSW , QLD , VIC , WA , SA

COZMOS: Phase I/Ib trial of Combined 5’azacitidine and carboplatin for recurrent/refractory paediatric brain and solid tumours

Brain cancer: Medulloblastoma

Status: Open QLD , VIC , WA

SJ ELiOT: Phase 1 Evaluation of LY2606368, a CHK inhibitor, in combination with cyclophosphamide or gemcitabine for children & adolescents with recurrent medulloblastoma tumours.

Hypermutant Cancers

Status: Open NSW , QLD , SA

Hypermutant Cancers Trial: A Pilot Study of Nivolumab in Paediatric Patients with Hypermutant Cancers

Neuroblastoma

Status: Open NSW , VIC , WA

LINES: European Low and Intermediate Risk Neuroblastoma (Phase III SIOPEN study)

Peripheral neuroblastic tumours

Status: Open NSW , QLD , TAS , VIC , WA

SIOPEN SCI Registry: Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting with Spinal Canal Involvement

Progressive high-risk solid tumours or central nervous system tumours

Status: Open NSW , WA

INFORM2 NivEnt: Phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies

Diffuse Intrinsic Pontine Glioma (DIPG)

Status: Open QLD , VIC , WA

ReRAD: A Phase II Canadian Paediatric Brain Tumour Consortium Study of Re – Irradiation as Treatment of Progressive or Recurrent Diffuse Intrinsic Pontine Glioma

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