Last Updated | 31 March 2026

CDRB436G2201

Phase II Open-label Global Study to Evaluate the Effect of Dabrafenib in Combination With Trametinib in Children and Adolescent Patients With BRAF V600 Mutation Positive Low Grade Glioma (LGG) or Relapsed or Refractory High Grade Glioma (HGG)
External Registry
Site Status Royal Children's Hospital
Queensland Children's Hospital (QLD)
John Hunter Children's Hospital (NSW)
Sydney Children's Hospital (NSW)
Monash Health Clayton (VIC)
Royal Children's Hospital (VIC)
Women's and Children's Hospital (SA)
Perth Children's Hospital (WA)
Royal Hobart Hospital (TAS)
Children's Hospital at Westmead (NSW)
Starship Children's Hospital (NZ)
Christchurch Hospital (NZ)
Preparing to Open
Open
Temporarily Closed
Closed
Complete
Adult Sites These sites are not monitored. Status may vary.
Diagnosis Stage Relapsed/Refractory
National Sponsor Novartis Pharmaceuticals
Open Date 24/10/2017
Conditions Astrocytoma
Oligodendroglioma
Glioblastoma
Glioma
Gangliocytoma
Ganglioglioma
Patient Range 3 years25 years
Disease Type Brain and Spinal (Central Nervous System) Tumours
Study Type Interventional
International Sponsor N/A

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