Australian & New Zealand Childrens Haematology/Oncology Group

Clinical Trials

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Adamantinomatous Craniopharyngioma

Status: In Development

CONNECT2108: Phase 2 Study of the MEK inhibitor MEKTOVI® (binimetinib) for the treatment of Progressive/Recurrent Pediatric Adamantinomatous Craniopharyngioma

Medulloblastoma

Status: In Development

SJiMB21: Phase 2 Study of Molecular and Clinical Risk-Directed Therapy for Infants and Young Children with Newly Diagnosed Medulloblastoma

Acute Lymphoblastic Leukemia

Status: Preparing to Open

RAVEN: A phase I/II trial treating relapsed acute lymphoblastic leukemia with venetoclax and navitoclax

Adamantinomatous Craniopharyngioma

Status: Open | WA

CONNECT1905: Phase 2 Study of Systemic IL-6 Receptor Antagonist ACTEMRA® (tocilizumab) for the treatment of Progressive/Recurrent Pediatric Adamantinomatous Craniopharyngioma

Medulloblastoma

Status: Open | NSW , VIC

MetMED: Phase III randomized double-blind placebo-controlled trial of metformin for white matter repair and cognitive recovery in paediatric brain tumour patients

Diffuse Midline Gliomas

Status: Open | NSW , QLD , VIC , WA , SA

PNOC-022 (DMG-ACT): A Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas including Diffuse Intrinsic Pontine Gliomas at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression.

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